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Paclitaxel 现货促销，7折优惠！
477 人阅读发布时间：2013-05-28 13:54
产品名称：Paclitaxel
化学名：N-BENZYL-BETA-PHENYLISOSERINE ESTER
CAS No： 33069-62-4
分子式：C47H51NO14
分子量：853.92
纯度：99%
溶解度：Soluble to 25 mM in ethanol and to 100 mM in DMSO with gentle warming
保存：2-8°C
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货号：abs810020
规格： 大包装询价
货号 产品名称 规格
abs810020a Paclitaxel 5mg
abs810020b Paclitaxel 10mg
abs810020c Paclitaxel 25mg
abs810020d Paclitaxel 50mg
abs810020e Paclitaxel 100mg
库存：现货
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生物活性：
Antitumor agent; promotes and stabilizes tubulin polymerization, causing cell cycle arrest. Induces
autocatalytic activation of caspase-10 in CCRF-HSB-2cells, triggering apoptosis.
It selectively inhibits the proliferation of human endothelial cells (ECs) at ultra low concentrations (0.1-100
pM), while it inhibits non-endothelial type human cells at 10(4) - to 10(5) -fold higher concentrations, with
IC50 = 1-10 nM. The selectivity of paclitaxel inhibition of cell proliferation is also species specific, as mouse
ECs are not sensitive to paclitaxel at ultra low concentrations. They are inhibited by higher concentrations
of paclitaxel with IC50 = 1-10 nM. Inhibition of human ECs by paclitaxel at ultra low concentrations does
not affect the cellular microtubule structure. Paclitaxel blocks cells in G2-M, and this may result in a
schedule-dependent effect on paclitaxel cytotoxicity.