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Okadaic Acid 现货促销，7折优惠！
595 人阅读发布时间：2013-05-28 13:55
产品名称：Okadaic Acid
化学名：9,10-Deepithio-9,10-didehydroacanthifolicin
CAS No：78111-17-8
分子式：C44H68O13
分子量：805.00
纯度：>98%
溶解度：Soluble in ethanol (25 mg/ml), DMSO (25 mg/ml), methanol (≥1 mg/ml)
保存： -20° C
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货号：abs810018
规格： 大包装询价
货号 产品名称 规格
abs810018a Okadaic Acid 250ug
abs810018b Okadaic Acid 500ug
abs810018c Okadaic Acid 1mg
abs810018d Okadaic Acid 2mg
abs810018e Okadaic Acid 5mg
库存：现货
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生物活性：
Okadaic acid is a naturally occurring polyether toxin that was originally derived from marine dinoflagellates,
Prorocentrium spp.. It is a reversible, potent and selective inhibitor of two serine threonine protein
phosphatases: PP2A-C (PP2A) which is inhibited completely at 1 nM and PP1 which is inhibited at higher
concentrations (IC50= 10-15 nM). PP2B is much less sensitive to okadaic acid than PP1, while PP2C is not
inhibited. This selectivity is the basis for an improved identification and quantification procedure for these
enzymes. The hydrophobic backbone of okadaic acid enables it to enter cells where it stimulates
intracellular protein phosphorylation. It mimics the effects of insulin, enhances transmitter release at
neuromuscular junctions, causes vasodilation and is a very potent tumor promoter.
Okadaic acid is an extremely useful tool for studying cellular processes that are regulated by
phosphorylation. Okadaic Acid is an activator of PKC.