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Staurosporine 现货促销，7折优惠！
537 人阅读发布时间：2013-05-28 13:53
产品名称：Staurosporine
化学名：antibiotic AM-2282 or STS
CAS No：62996-74-1
分子式：C28H26N4O3
分子量：466.53
纯度：≥99%
溶解度：Soluable in DMSO, solubility in ethanol or water is low
保存：-20 ºC
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货号：abs810006
规格： 大包装询价
货号 产品名称 规格
abs810006a Staurosporine 5mg
abs810006b Staurosporine 10mg
abs810006c Staurosporine 25mg
abs810006d Staurosporine 50mg
abs810006e Staurosporine 100mg
库存：现货
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生物活性：
Staurosporine is the precursor of the novel protein kinase inhibitor midostaurin (PKC412). Staurosporine is
a potent inhibitor of many, many kinases including protein kinase C (IC50 = 0.7 nM), protein kinase A (IC50
= 7 nM), and protein kinase G.
The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of
ATP binding to the kinase. This is achieved through the stronger affinity of staurosporine to the ATP-binding
site on the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many
kinases with high affinity, though with little selectivity. Structural analysis of kinase pockets demonstrated
that main chain atoms which are conserved in their relative positions to staurosporine contributes to
staurosporine promiscuity. This lack of specificity has precluded its clinical use, but has made it a valuable
research tool. In research, staurosporine is used to induce apoptosis. The mechanism of how it mediates
this is not well understood. It has been found that one way in which staurosporine induces apoptosis is by
activating caspase-3.