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Cholera Toxin B Subunit 现货促销，7折优惠！
870 人阅读发布时间：2013-05-28 13:55
产品名称：CHOLERA TOXIN B SUBUNIT, 霍乱毒素 B 亚单位
化学名：Choleragenoid; CTB；CTxB
CAS No：131096-89-4
分子式：
分子量：
纯度：≥95% (SDS-PAGE)
溶解度：H2O: soluble 1mg/mL (stable indefinitely at 2-8 °C), Reconstitute with water to a final concentrationof
1 mg cholera toxin B subunit per ml. Swirl bottles gently during reconstitution. Avoid vigorous pipetting
of solutions that may lead to foaming.Solutions can be filtered through a 0.2 mm filter.
保存：2-8C, The product, as supplied, is stable 2 years when stored properly. Solutions are stable for at least 3
months when stored at 2–8 C. DO NOT FREEZE.
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货号：abs80001
规格： 大包装询价
货号 产品名称 规格
abs80001 CHOLERA TOXIN B SUBUNIT 1mg
库存：现货
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生物活性：
Cholera toxin belongs to the AB5 –subunit family oftoxins.The native hexameric protein has a molecular mass of
~85 kDa and contains two subunits. It consists of a single A subunit (~27.2 kDa), responsible for the
ADP-ribosylation activity, and five B subunits(~11.6 kDa each), which are arranged as a pentameric ring with an
apparent 5-fold symmetry and are associated with the cell surface receptor binding and subsequent
internalization (transmembrane transport)of the enzymatic component.
Cholera toxin and its purified A subunit are frequently used for the study of signal transduction mechanisms. In
addition,cholera toxin acts as an adjuvant through the stimulation of B lymphocytes. The cholera toxin B subunit
alone is used for track tracing in neurological research, taking advantage of GM1 ganglioside binding and
retrograde transport.Tissue culture cells treated with cholera toxin are not killed and tissues of animals do not
become necrotic.
The B subunit is non-toxic to cells and possesses no intrinsic adenylate cyclase activity. The cholera toxin B
subunit (CTB) attaches to cells by binding to ganglioside GM1.8 CTB has been shown to be a good label for
microglial cells (due to the enrichment of ganglioside GM1 on their cell surface), but not for oligodendrocytes or
astrocytes. The B subunit has been reported to be an excellent tracer for the study of axonal transport using
immunohistochemical methods. Recently it has been widely used as a marker of membrane lipid rafts, which are
membrane microdomains enriched with cholestrol and sphingolipids. These lipid rafts have an important role in
cell signaling and protein trafficking.