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Cyclosporin A 现货促销，7折优惠！
568 人阅读发布时间：2013-05-28 13:56
产品名称：Cyclosporin A
化学名： ol27-400
CAS No：59865-13-3
分子式：C62H111N11O12
分子量：1202.61
纯度：>99 %
溶解度：Soluble to 100 mM in DMSO and to 50 mM in ethanol
保存：-20°C
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货号：abs810016
规格： 大包装询价
货号 产品名称 规格
abs810016a Cyclosporin A 5mg
abs810016b Cyclosporin A 10mg
abs810016c Cyclosporin A 25mg
abs810016d Cyclosporin A 50mg
abs810016e Cyclosporin A 100mg
库存：现货
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生物活性：
Cyclosporin A is a metabolite of the fungi Trichoderma polysporum, Cyclosporin A (CsA) is a cyclic
polypeptide consisting of 9 amino-acids to inhibit nitric oxide synthesis induced by interleukin 1alpha,
lipopolysaccharides and TNFα. CsA is an immunosuppressant. Studies in animals indicate that cyclosporin
inhibits the development of cell-mediated reactions, including allograft immunity, delayed cutaneous
hypersensitivity, experimental allergic encephalomyelitis, Freund's adjuvant arthritis, graft-versus-host
disease and also T-cell dependent antibody production. Also inhibits lymphokine production and release
and appears to block resting lymphocytes in the G0 or G1 phase of the cell cycle. CsA binds to cyclophilin
and inhibits the T-cell receptor signal transduction pathway via the formation of cyclpsporin A-cyclophilin
complex. The CsA-cyclophilin complex inhibits calcineurin, a type 2B phosphatase. Calcineurin inhibition
interferes with other physiological processes as well. It inhibits mitochondrial permeability transition pore
opening. However, pore inhibition becomes less efficient at increasing Ca2+ loads and inhibition is transient.
Inhibits staurosporin-induced apoptosis in cultured neural cells and rotenone-induced apoptosis in PC-12
cells