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LY 294002,154447-36-6
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LY 294002 现货促销，7折优惠！
700 人阅读发布时间：2013-05-28 14:01
产品名称：LY 294002
化学名：2-[4-MORPHOLINYL]-8-PHENYL-1[4H]-BENZOPYRAN-4-ONE
CAS No：154447-36-6
分子式：C19H17NO3
分子量：307.34
纯度：>99%
溶解度：DMSO ≥36mg/mL 、Ethanol ≥21mg/mL
保存：-20°C
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货号：abs810001
规格： 大包装询价
货号 产品名称 规格
abs810001a LY 294002 5mg
abs810001b LY 294002 10mg
abs810001c LY 294002 25mg
abs810001d LY 294002 50mg
abs810001e LY 294002 100mg
库存：现货
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生物活性：
LY 294002 has been shown to be a potent inhibitor of PI 3-kinase activity, acting as a competitive inhibitor
for ATP binding site of the enzyme. LY 294002 inhibits cell proliferation of choroidal melanoma OCM-1 cells,
the IC50 was observed about 10 μM, a concentration higher than, but compatible with, the one (1.4 μM)
reported for in vitro inhibition of PI 3-kinase activity.
LY 294002 is also an inhibitor of casein kinase II. Application of LY 294002 causes a substantial
acceleration of MEPP frequency (150 μM) at the frog neuromuscular junction, through a mechanism that is
independent of intraterminal calcium. LY 294002 causes the release of MEPPs through a perturbation of
synaptotagmin function.