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Bay 11-7082,19542-67-7
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Bay 11-7082现货促销，7折优惠！
573 人阅读发布时间：2013-05-28 14:01
产品名称：BAY 11-7082
化学名：(E)-3-[(4-methylphenylsulfonyl]-2- propenenitrile
CAS No：19542-67-7
分子式：C10H9NO2S
分子量：207.25
纯度：99%
溶解度：Soluble to 25 mM in ethanol and to 100 mM in DMSO
保存：4°C 或 -20℃
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货号：abs810013
规格： 大包装询价
货号 产品名称 规格
abs810013a BAY 11-7082 5mg
abs810013b BAY 11-7082 10mg
abs810013c BAY 11-7082 25mg
abs810013d BAY 11-7082 50mg
abs810013e BAY 11-7082 100mg
库存：现货
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生物活性：
BAY 11-7082, a potential anti-inflammatory agent, is an irreversible inhibitor of cytokine-inducible IκBα
(nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor,alpha; NFKBIA) phosphorylation
(IC50=10 μM). In intact HUVECs it inhibits TNFα-induced phosphorylation and degradation of IκBα (NFKBIA)
without affecting constitutive phosphorylation. Inhibition of ιBα phosphorylation and degradation results in
the inactivation of NF κ B and thereby inhibits the expression of endothelial-leukocyte adhesion molecules:
E-selectin, VCAM-1 and ICAM-11.
BAY 11-7082 has also demonstrated stimulation of the stress-activated protein kinases, p38 and JNK-1.
BAY 11-7082 is an inhibitor of IKK α.