
产品名称:SP600125
化学名:1,9-Pyrazoloanthrone
CAS No: 129-56-6
分子式:C14H8N2O
分子量:220.23
纯度:≥99%
溶解度:Soluable in DMSO, solubility in ethanol or water is low
保存:-20 ºC
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货号:abs810008
规格: 大包装询价
货号 产品名称 规格
abs810008a SP600125 5mg
abs810008b SP600125 10mg
abs810008c SP600125 25mg
abs810008d SP600125 50mg
abs810008e SP600125 100mg
库存:现货
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生物活性:
SP600125 is a chemical compound that is a derivative of anthrone. It is used in biochemical studies as an
inhbitor of c-Jun N-terminal kinases (JNKs). It is a novel, potent and selective JNK-1,-2, and -3 inhibitor (Ki
= 0.19 µM). In cells, SP600125 caused a dose-dependent inhibition of the phosphorylation of c-Jun, the
expression of inflammatory genes IL-2, COX-2, TNF-α, IFN-γ, and blocked the activation and differentiation
of primary human CD4 cell cultures.