- 移动端
爱必信(上海)生物科技有限公司品牌商
14 年
手机商铺
商家活跃：
产品热度：
- NaN
- 0
- 0
- 2
- 2
AG 490,133550-30-8
￥221 - 1042
推荐产品
公司新闻/正文
AG 490 现货7折促销，史上最低价~
1182 人阅读发布时间：2013-05-28 14:04
产品名称：AG-490
化学名：(E)-2-Cyano-3-(3,4-dihydrophenyl)-N-(phenylmethyl)-2-propenamide
CAS No：133550-30-8
分子式：C17H14N2O3
分子量：294.31
纯度：98%
溶解度：Soluble in DMSO (30 mg/ml), DMF (40 mg/ml), ethanol (15 mg/ml)
保存：室温或 -20℃
--------------------------------------------------------------------------------------------------------
货号：abs810014
规格： 大包装询价
货号 产品名称 规格
abs810014a AG-490 5mg
abs810014b AG-490 10mg
abs810014c AG-490 25mg
abs810014d AG-490 50mg
abs810014e AG-490 100mg
库存：现货
-----------------------------------------------------------------------------------------------------------
生物活性：
AG-490 is a tyrosine kinase inhibitor of JAK2, EGFR, and Neu that belongs to the family of tyrphostins.
In acute lymphoblastic leukemia studies the compound has been reported to inhibit JAK2 from B cell
precursors. Additionally, AG-490 has been observed to block cytokine-induced activation of JAK2 in
eosinophils and STAT3 activation in T cell lymphoma cells. Unlike other kinase inhibitors, AG-490 does
not inhibit JAK1, Lck, Btk, Tyk2, Syk, Lyn, and Src. Research indicates that AG-490 inhibits IL-7
mediated proliferation. Inhibition of Jak kinase activity by AG-490 leads to lower levels of p85
phosphorylation and p-13 kinase activation. AG-490 is an inhibitor of JAK3.