Enzyme、Receptor、Ion channel 等调节剂
1063 人阅读发布时间：2014-09-24 11:10
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| 最专业、最全面的生化试剂供应商 |
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Manipulate receptor and enzyme function with
inhibitors, activators, agonists and antagonists. |
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Enzyme inhibitors
and activators |
Receptor agonists
and antagonists |
Ion channel blockers
and modulators |
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> Clathrin
> CAMK
> AMPK
> HDAC
> Rho |
> MAPK
> Caspase
> PI3K/Akt
> ATPase |
> Glutamate
> GPCR
> Muscarinic
> Adenosine
>Adrenoceptors |
> GABA
> Nicotinic
> Purinergic
> Serotonin |
> Sodium
> Calcium
> Ionophores
> Chelators |
> Potassium
> TRP
> Indicators |
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| Advantages of small-molecule inhibitors |
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Low compromise to
protein-protein interactions |
Range of selectivity |
Rapid effects for temporal control |
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Cell-permeable and blood-brain
barrier permeable options |
Reversible and long-term effects |
Easy to use |
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Quality guaranteed |
High purity compounds |
Technical support |
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| Guidelines for small-molecule inhibitors |
1. Check publications for an insight into selectivity, potency advantages and disadvantages of chosen inhibitors in your system
2. Always check there is a rational correlation between biochemical inhibition in vitro and effective inhibition in cells |
3. Ideally you should use an inhibitor at the lowest concentration in order to minimize off-target effects
4. Where available use multiple inhibitors to your target of interest in parallel experiments to
back up your observations
5. Where available, use positive and negativecontrols
6. If possible rule out off-target effects by using
drug-resistant models |
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| Study receptor and signaling pathways with our exceptional quality range including: |
| Enzyme & Signaling inhibitors & activators |
| Product Name |
Description |
Citations |
Purity |
Product code |
| Y-27632 dihydrochloride |
Selective Rho kinase inhibitor |
13 |
>99% |
ab120129 |
| Pitstop 2™ |
Novel, selective cell-permeable clathrin inhibitor |
14 |
|
ab120687 |
| Amyloid β Peptide (1-42) (human) |
Predominant amyloid-β protein fragment |
2 |
>95% |
ab120301 |
| Z-VAD(OMe)-FMK |
Cell-permeable, irreversible pan-caspase inhibitor |
|
>90% |
ab120487 |
| (±)-Blebbistatin |
Potent, selective inhibitor of myosin II |
1 |
>98% |
ab120425 |
| FK506 (Tacrolimus) |
Immunosuppressant |
1 |
>98% |
ab120223 |
| FCCP |
Mitochondrial oxidative phosphorylation inhibitor |
2 |
>99% |
ab120081 |
| Doxorubicin hydrochloride |
Topoisomerase II inhibitor. Antibiotic with cytotoxic actions. |
|
>98% |
ab120629 |
| NKH 477 (Colforsin daropate) |
Adenylyl cyclase activator |
|
>98% |
ab120190 |
| A 769662 |
AMP-activated protein kinase activator |
2 |
>99% |
ab120335 |
| Forskolin |
Adenylyl cyclase activator |
5 |
>98% |
ab120058 |
| Dyngo-4a™ |
Novel, highly potent dynamin inhibitor |
5 |
|
ab120689 |
| SL 327 |
MEK inhibitor |
6 |
>99% |
ab120082 |
| SB431542 |
ALK inhibitor |
3 |
>99% |
ab120163 |
| DAPT |
γ-secretase inhibitor |
2 |
>99% |
ab120633 |
| Dynasore |
Cell-permeable dynamin inhibitor |
7 |
>99% |
ab120192 |
| Phorbol 12-myristate 13-acetate (PMA) |
PKC activator |
3 |
>99% |
ab120297 |
| AICAR (Acadesine/AICA riboside) |
Cell-permeable activator of AMP-activated protein kinase |
|
>98% |
ab120358 |
| Z-VAD-FMK |
Irreversible general caspase inhibitor |
1 |
>98% |
ab120382 |
| Okadaic acid |
PP1 and PP2A inhibitor |
2 |
>98% |
ab120375 |
| STO-609 |
Potent, competitive, selective and cell-permeable inhibitor of CaM-KK |
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>98% |
ab141591 |
| Bafilomycin A1 |
Highly potent, selective (V)-ATPase inhibitor |
4 |
>98% |
ab120497 |
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| Ion channel modulators |
| Product Name |
Description |
Citations |
Purity |
Product code |
| Tetrodotoxin citrate |
Na+ channel blocker; water-soluble |
26 |
>98% |
ab120055 |
| Tetrodotoxin |
Na+ channel blocker |
88 |
>98% |
ab120054 |
| QX-314 bromide |
Na+ channel blocker |
8 |
>99% |
ab120117 |
| Ionomycin Ca2+ Salt |
Ca2+ ionophore |
2 |
>99% |
ab120116 |
| BAPTA-AM |
Selective Ca2+ chelator |
|
>98% |
ab120503 |
| Ionomycin (free acid) |
Ca2+ ionophore |
2 |
>99% |
ab120370 |
| SNX 482 |
R-Type Ca2+ (Cav 2.3) channel blocker |
1 |
>96% |
ab120259 |
| ω-Conotoxin GVIA |
Ca2+ channel blocker (N type) |
3 |
>96% |
ab120215 |
| Veratridine |
Na+ channel opener |
1 |
>97% |
ab120279 |
| HC-030031 |
TRPA1 blocker, orally active |
|
>99% |
ab120554 |
| Tertiapin Q |
Potent inward rectifier K+ channel blocker |
1 |
>99% |
ab120432 |
| Iberiotoxin |
Selective blocker of the high-conductance, Ca2+-activated K+ channel |
1 |
>95% |
ab120379 |
| Capsazepine |
VR1 antagonist |
6 |
>99% |
ab120025 |
| Apamin |
Blocker of small conductance Ca2+-activated K+ channels |
2 |
>95% |
ab120268 |
| SKF 96365 |
Blocker of TRP cation channels. Inhibits capacitative Ca2+ entry. |
3 |
>99% |
ab120280 |
| KB-R7943 |
NCX inhibitor. TRPC blocker. |
|
>99% |
ab120284 |
| Fura-2 AM |
Selective Ca2+ chelator; fluorescent indicator |
|
>95% |
ab120873 |
| L-cis-Diltiazem |
Selective cyclic nucleotide-gated channel blocker |
|
>98% |
ab120532 |
| Psalmotoxin-1 |
Potent, selective ASIC1a blocker |
1 |
>95% |
ab120483 |
| E-4031 dihydrochloride |
HERG K+ channel blocker |
1 |
>99% |
ab120158 |
| Charybdotoxin |
K+ channel blocker |
3 |
>98% |
ab120269 |
| (±)-BAYK8644 |
Potent L-type Ca2+ channel activator |
|
>99% |
ab120366 |
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