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发动蛋白(Dynamin）抑制剂
1187 人阅读发布时间：2014-08-28 11:30
发动蛋白(Dynamin）抑制剂
Dynamin is a key GTPase involved in various forms of endocytosis and is comprised of 3 major isoforms, all of which have four main functional domains.
In addition to being a key component of endocytosis, dynamin participates in cell cycle progression and has also been shown to have critical roles in centrosome cohesion and cytokinesis.
Dynamin inhibitors inhibit different domains of dynamin, leading to subsequent inhibition of endocytosis. Consequently, the dynamin inhibitors have wide-spread application allowing investigation of cell signalling pathways, the cell cycle and cellular division, in addition to other medical conditions such as cancer, neurological conditions and infectious diseases such as botulism and HIV.
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Code
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Name
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Details
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ab120474
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Dynamin Inhibitors: Dynole®Series Kit
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FuncS
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ab120473
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Dynamin Inhibitors: MiTMAB™ Series Kit
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FuncS
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ab120475
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Dynamin Inhibitors: Iminodyn™ Series Kit
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FuncS
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ab120468
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Dynamin Inhibitors Toolbox, kit from the MiTMAB™, Dynole™ and Iminodyn™ chemical series.
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FuncS
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ab120192
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Dynasore,
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Cell permeable dynamin inhibitor
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ab120689
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Dyngo® 4a (Dynasore (ab120192) analog.)
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Novel, highly potent dynamin inhibitor.
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ab141290
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Dynole® 2-24
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Novel, potent dynamin I and II inhibitor
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ab120464
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Dynole® 31-2
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Negative control for Dynole® 34-2
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ab120463
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Dynole® 34-2
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Potent dynamin I and dynamin II inhibitor
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ab120462
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Iminodyn™ 17
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Negative control for Iminodyn™ 22
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ab120461
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Iminodyn™ 22
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Potent, broad spectrum dynamin inhibitor
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ab120466
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MiTMAB™
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Cell permeable dynamin I and dynamin II inhibitor
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ab120467
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OcTMAB™
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Cell permeable dynamin I and dynamin II inhibitor
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ab120476
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Pro-Myristic Acid
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Negative control for MiTMAB™ and OcTMAB™
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ab120796
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Rhodadyn™ B10
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Negative control for Rhodadyn™ C10 (ab120795)
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ab120795
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Rhodadyn™ C10
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Highly potent cell permeable dynamin I inhibitor
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ab120465
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RTIL™ 13
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Potent dynamin I and II inhibitor
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References
Hill TA et al. Iminochromene inhibitors of dynamins I and II GTPase activity and endocytosis. J Med Chem 53:4094-102 (2010).
Read more (PubMed: 20426422) »
Read more (PubMed: 20426422) »
Hill TA et al. Inhibition of dynamin mediated endocytosis by the dynoles--synthesis and functional activity of a family of indoles. J Med Chem 25:3762-73 (2009).
Read more (PubMed: 19459681) »
Read more (PubMed: 19459681) »
Doherty GJ and McMahon HT. Mechanisms of endocytosis. Annu Rev Biochem 78:857-902 (2009).
Read more (PubMed: 19317650) »
Read more (PubMed: 19317650) »
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